Doom overturns frame of mind (4)
I believe the answer is:
mood
'frame of mind' is the definition.
(thesaurus)
'doom overturns' is the wordplay.
'overturns' is a reversal indicator.
'doom' in reverse letter order is 'MOOD'.
(Other definitions for mood that I've seen before include "Frame of mind" , "Disposition" , "State of mind, humour" , "Humour - bad temper" , "Doom (anag)" .)