Doomed fools suffering setback in exploit (8)

I believe the answer is:

destined

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'doomed' is the definition.
('destine' can be a synonym of 'doom')

I cannot understand how the rest of the clue works.

(Other definitions for destined that I've seen before include "Intended; doomed" , "Didn't see, being fated" , "Fated, fore-ordained" , "Intended (for a particular end)" , "Designated" .)

I've seen this clue in The Telegraph and The Sun.

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