Doubtful remedies; no way with liquors (8)
I believe the answer is:
nostrums
'doubtful remedies' is the definition.
'nostrums' can be an answer for 'remedies' (nostrum is a kind of remedy). I am not sure about the 'doubtful' bit.
'no way with liquors' is the wordplay.
'way' becomes 'st' (abbreviation for street).
'with' means one lot of letters go next to another.
'liquors' becomes 'rums' (rum is a kind of liquor).
'no'+'st'+'rums'='NOSTRUMS'
Can you help me to learn more?
(Other definitions for nostrums that I've seen before include "Questionable medicines" , "Quack remedies" , "Panaceas or cure-alls" , "quack medicines" , "Hypothetical remedies for all ills" .)