Dr No with strange ploy for domination (8)
I believe the answer is:
monopoly
'domination' is the definition.
(I've seen this before)
'dr no with strange ploy' is the wordplay.
'dr' becomes 'mo' (abbreviation for medical officer).
'with' says to put letters next to each other.
'strange' is an anagram indicator.
'ploy' with letters rearranged gives 'poly'.
'mo'+'no'+'poly'='MONOPOLY'
'for' is the link.
(Other definitions for monopoly that I've seen before include "No competition" , "Market in which there are many buyers but only one seller" , "Exclusive control or possession of something" , "control of market" , "Situation of one company's dominance in a particular market" .)