Dram from hotel consumed by drunk (4)
I believe the answer is:
shot
'dram' is the definition.
(thesaurus)
'hotel consumed by drunk' is the wordplay.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'consumed by' is an insertion indicator (inserted letters get consumed).
'drunk' becomes 'sot' (both can mean someone who drinks too much).
'h' inserted into 'sot' is 'SHOT'.
'from' acts as a link.
(Other definitions for shot that I've seen before include "Firing of a gun" , "Hit by gun" , "streaked with colour" , "completely gone" , "Small drink; photo" .)