Dramatic work to approach doggedly after vacation (6)
I believe the answer is:
comedy
'dramatic work' is the definition.
'approach doggedly after vacation' is the wordplay.
'approach' becomes 'come' (I've seen this before).
'after vacation' means to remove the middle letters (the inside letters must vacate).
'doggedly' with its centre removed is 'dy'.
'come'+'dy'='COMEDY'
'to' acts as a link.
(Other definitions for comedy that I've seen before include "Humour" , "Dante's divine work" , "Form of light entertainment" , "A funny play or farce" , "Amusing drama" .)