Drink and dope upset you and me (5)
I believe the answer is:
negus
'drink' is the definition.
(negus is a kind of drink)
'dope upset you and me' is the wordplay.
'dope' becomes 'gen' (I've seen this in other clues).
'upset' says the letters should be written in reverse.
'you and me' becomes 'us'.
'gen' in reverse letter order is 'neg'.
'neg'+'us'='NEGUS'
'and' is the link.
(Other definitions for negus that I've seen before include "Hot wine" , "Warm drink" , "Hot, spiced alcoholic drink" , "Title of Emperor of Ethiopia" , "Hot spiced port with lemon" .)