Drink starts to kick in rapidly (3)
I believe the answer is:
kir
'drink' is the definition.
(I've seen this before)
'starts to kick in rapidly' is the wordplay.
'starts to' indicates taking the first letters.
The initial letters of 'kick in rapidly' is 'KIR'.
(Other definitions for kir that I've seen before include "White wine with blackcurrant syrup" , "Cassis-flavoured wine" , "Blackcurrant drink" , "Drink of white wine and cassis" , "One that's drunk" .)