Drinking makes him so thick-headed! (3)
I believe the answer is:
sot
'drinking makes him' is the definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
'so thick-headed' is the wordplay.
'thick-headed' becomes 't' (this could be a standard abbreviation I've not previously seen).
'so'+'t'='SOT'
Can you help me to learn more?
(Other definitions for sot that I've seen before include "One drinks" , "drunk" , "Habitual drinker" , "Boozer" , "Habitual drunkard" .)