Drive the American car Ed repaired round (7)
I believe the answer is:
crusade
'drive' is the definition.
('crusade' can be a synonym of 'drive')
'the american car ed repaired round' is the wordplay.
'the american' becomes 'us'.
'repaired' indicates an anagram.
'round' means one lot of letters goes inside another.
'car'+'ed'='cared'
'cared' with letters rearranged gives 'crade'.
'us' put within 'crade' is 'CRUSADE'.
(Other definitions for crusade that I've seen before include "Advertising campaign" , "Drive" , "Medieval Christian military expedition to capture the Holy Land" , "Religious war" , "religious campaign" .)