Drug manufactured in Paris (7)
I believe the answer is:
aspirin
'drug' is the definition.
(aspirin is a kind of drug)
'manufactured in paris' is the wordplay.
'manufactured' is an anagram indicator.
'in'+'paris'='inparis'
'inparis' anagrammed gives 'ASPIRIN'.
(Other definitions for aspirin that I've seen before include "Pain-relieving drug made in Paris" , "Anti-inflammatory drug" , "answer to pain?" , "Headache killer?" , "headache cure" .)