Crossword Genius

Drug, one fuelling a short run (7)

Ross

I believe the answer is:

aspirin

I'm a little stuck... Click here to teach me more about this clue!

'drug' is the definition.
(aspirin is a kind of drug)

'one fuelling a short run' is the wordplay.
I cannot quite see how this works, but
'one' could be 'i' (roman numeral) and 'i' is present in the answer.
'a' is present in the answer.
'run' could be 'r' (cricket abbreviation) and 'r' is found in the answer.
The remaining letters 'spin' is a valid word which might be clued in a way I don't understand.
This may be the basis of clue (or it may be nonsense).

Can you help me to learn more?

(Other definitions for aspirin that I've seen before include "Commonly used pain-killer" , "Pain-relieving tablet" , "Analgesic compound" , "number" , "Analgesic over in Paris" .)

I've seen this clue in The Guardian.
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