Drugs? Being on these, one would be broke (6)
I believe the answer is:
uppers
I believe this is a double definition.
'drugs?' is the first definition.
(upper is a kind of drug)
'being on these one would be broke' is the second definition.
(someone 'on their uppers' has no money)
(Other definitions for uppers that I've seen before include "Drugs" , "The 25 [PENNILESS] are on these" , "Skint when on these" , "Out of luck, one may be on these" , "pills" .)