Drugs confused the man — is it a sin? (14)
I believe the answer is:
antihistamines
'drugs' is the definition.
(antihistamine is a kind of drug)
'confused the man is it a sin?' is the wordplay.
'confused' indicates an anagram.
'the'+'man'+'is'+'it'+'a'+'sin'='themanisitasin'
'themanisitasin' is an anagram of 'ANTIHISTAMINES'.
I've seen this clue in The Times.
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