Drunk, refuse third of vodka (6)
I believe the answer is:
wasted
'drunk' is the definition.
(I've seen this in another clue)
'refuse third of vodka' is the wordplay.
'refuse' becomes 'waste' (I've seen this before).
'third of vodka' becomes 'd' (3rd letter of 'vodka').
'waste'+'d'='WASTED'
(Other definitions for wasted that I've seen before include "Not used to good advantage" , "Frittered away" , "Dissipated; atrophied" , "Blown" , "Used to no purpose" .)