Drunken nurse on the rebound breaks into drunken diatribe (10)
I believe the answer is:
inebriated
'drunken' is the definition.
(synonyms)
'nurse on the rebound breaks into drunken diatribe' is the wordplay.
'nurse' becomes 'EN' (abbreviation for state-enrolled nurse).
'on the rebound' says the letters should be written in reverse (to rebound is to go backwards).
'breaks into' indicates putting letters inside (inserted letters break into the word).
'drunken' is an anagram indicator.
'en' in reverse letter order is 'ne'.
'diatribe' with letters rearranged gives 'ibriated'.
'ne' inserted into 'ibriated' is 'INEBRIATED'.
(Other definitions for inebriated that I've seen before include "Drunk" , "Tipsy" , "Bombed" , "wasted" .)