Dry area with 500 sick trees (6)
I believe the answer is:
desert
'dry area' is the definition.
'desert' can be an answer for 'area' (desert is a kind of area). I am not sure about the 'dry' bit.
'with 500 sick trees' is the wordplay.
'with' means one lot of letters go next to another.
'500' becomes 'd' (Roman numeral for 500).
'sick' is an anagram indicator.
'trees' with letters rearranged gives 'esert'.
'd'+'esert' is 'DESERT'.
Can you help me to learn more?
(Other definitions for desert that I've seen before include "Abandon in wasteland" , "Wild" , "Run away (from army)" , "Abandon; barren waste" , "Run away; desolate area" .)