Dry up with Mr James in muddle (7)
I believe the answer is:
disturb
'muddle' is the definition.
(thesaurus)
'dry up with mr james' is the wordplay.
'dry' becomes 'brut' (type of wine).
'up' says the letters should be written in reverse (in down clue: letters go upwards).
'with' is a charade indicator (letters next to each other).
'mr james' becomes 'dis' (I can't explain this - if you can you should believe this answer much more).
'brut' in reverse letter order is 'turb'.
'turb' after 'dis' is 'DISTURB'.
'in' acts as a link.
Can you help me to learn more?
(Other definitions for disturb that I've seen before include "Trouble - interrupt" , "Interrupt; upset" , "Upset - agitate" , "Break" , "Interrupt, annoy" .)