Du Pre's instrument (5)
I believe the answer is:
cello
'du pre's instrument' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for cello that I've seen before include "has strings attached" , "Tortelier's instrument" , "Played by Rostropovich" , "Viola's bigger brother?" , "Large stringed instrument" .)