Duke — a famous one — losing weight in house (8)
I believe the answer is:
dwelling
'house' is the definition.
(somewhere people live)
'duke a famous one losing weight' is the wordplay.
I cannot really see how this works, but
'duke' could be 'd' (abbreviation) and 'd' is found within the answer.
'one' could be 'i' (Roman numeral) and 'i' is located in the answer.
'weight' could be 'w' (short for weight) and 'w' is found within the answer.
This may be the basis of the clue (or it may be nonsense).
'in' acts as a link.
Can you help me to learn more?
(Other definitions for dwelling that I've seen before include "Habitation" , "Home" , "Harping" , "house" , "Place of residence" .)