Ease of distributing cocaine in U.S. (11)
I believe the answer is:
insouciance
'ease' is the definition.
(thesaurus)
'distributing cocaine in u s' is the wordplay.
'distributing' indicates anagramming the letters.
'cocaine'+'in'+'u'+'s'='cocaineinus'
'cocaineinus' with letters rearranged gives 'INSOUCIANCE'.
'of' acts as a link.
(Other definitions for insouciance that I've seen before include "Casual unconcern" , "Lack of concern" .)