East to west, head for German city (5)
I believe the answer is:
essen
'german city' is the definition.
(city in Germany)
'east to west head' is the wordplay.
'east' becomes 'e' (abbreviation).
'to west' says the letters should be written backwards (the letters are written right to left).
'head' becomes 'ness' (ness is a headland).
'ness' in reverse letter order is 'ssen'.
'e'+'ssen'='ESSEN'
'for' acts as a link.
(Other definitions for essen that I've seen before include "German industrial city on the Ruhr" , "city in the Ruhr valley" , "German place name" , "European city" , "Industrial centre of the Ruhr" .)