Eastern friend keeping an issue (7)
I believe the answer is:
emanate
'issue' is the definition.
(both can mean to give out or radiate)
'eastern friend keeping an' is the wordplay.
'eastern' becomes 'e'.
'friend' becomes 'mate' (mate is a kind of friend).
'keeping' indicates putting letters inside (some letters kept inside).
'mate' placed around 'an' is 'manate'.
'e'+'manate'='EMANATE'
(Other definitions for emanate that I've seen before include "Proceed or issue forth" , "Give out, emit" , "Send out" , "Issue or originate from manatee" , "Issue or spread out from a source" .)