Eccentric four about to make a lot of fuss (6)
I believe the answer is:
furore
'fuss' is the definition.
(I have seen 'Public fuss' mean 'furore' so perhaps 'fuss' could also mean 'furore')
'eccentric four about' is the wordplay.
'eccentric' indicates anagramming the letters.
'about' becomes 're' ('re' means regarding or about).
'four' is an anagram of 'furo'.
'furo'+'re'='FURORE'
'to make a lot of' is the link.
This may not be right. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for furore that I've seen before include "Frenzied excitement, uproar" , "Turmoil, uproar" , "Outbreak of public anger or excitement" , "Sudden outburst, uproar" , "Uproar, hullabaloo" .)