Eeyore's unfortunate blemish (7)
I believe the answer is:
eyesore
'blemish' is the definition.
(eyesore is a kind of blemish)
'eeyore's unfortunate' is the wordplay.
'unfortunate' indicates anagramming the letters.
'eeyores' anagrammed gives 'EYESORE'.
(Other definitions for eyesore that I've seen before include "It's offensively ugly" , "it looks bad" , "Something ugly to look at" , "Ugly building" , "Monstrosity" .)