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Effect of spiked drink with bit of temazepam in it (3,2)

Ross

I believe the answer is:

set up

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'effect' is the definition.
(synonyms)

I don't understand the remainder of the clue.

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(Other definitions for set up that I've seen before include "The way something is arranged" , "Arrangement; trick" , "Established" , "Fool" , "Arrange; prepare; build" .)

I've seen this clue in The Sunday Times and The Times.
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