Effective for you and me, we end almost full (6)
I believe the answer is:
useful
'effective' is the definition.
(associated in meaning)
'you and me we end almost full' is the wordplay.
'you and me' becomes 'us'.
'end' indicates one should take the final letters.
'almost' means to remove the last letter (almost the whole word is kept).
The final letter of 'we' is 'e'.
'full' with its final letter taken off is 'ful'.
'us'+'e'+'ful'='USEFUL'
'for' is the link.
(Other definitions for useful that I've seen before include "Effective" , "Expedient" , "Advantageous - efficacious" , "Handy; very able" , "Advantageous, serviceable" .)