Effete blockbuster direction (7)
I believe the answer is:
epicene
'effete' is the definition.
(I've seen this before)
'blockbuster direction' is the wordplay.
'blockbuster' becomes 'epic' (I've seen this before).
'direction' becomes 'ene' (ENE is an example).
'epic'+'ene'='EPICENE'
(Other definitions for epicene that I've seen before include "Sexless" , "Having characteristics of both sexes - or of none" , "Effeminate, effete" , "Hermaphroditic" , "Unisex" .)