Employ Sue for a change (3)
I believe the answer is:
use
'employ' is the definition.
(synonyms)
'sue for a change' is the wordplay.
'for a change' is an anagram indicator.
'sue' anagrammed gives 'USE'.
(Other definitions for use that I've seen before include "Sue for employment" , "Habitually employ" , "Take drugs regularly" , "Employ or exploit" , "Employ - custom" .)