Enchantress in Greek mythology who detained Odysseus on her island (5)
I believe the answer is:
circe
(Other definitions for circe that I've seen before include "Enchantress encountered by Odysseus" , "Enchanting female" , "she's into 20 [WITCHCRAFT]" , "Greek sorceress who detained Odysseus on her island" , "Greek sorceress who turned men into swine" .)