Enclave of near eastern region? (4)
I believe the answer is:
area
'region?' is the definition.
(area is a kind of region)
'enclave of near eastern' is the wordplay.
'enclave of' indicates the answer is hidden within the clue.
'AREA' can be found hidden inside 'near eastern'.
(Other definitions for area that I've seen before include "Speaking formally to (someone)" , "Extent of a two-dimensional surface" , "'Tract, region (4)'" , "Space for a specific purpose, say picnic" , "Region; extent of a surface" .)