Encourage female to abandon a facelift -- it melted! (10)
I believe the answer is:
facilitate
'encourage' is the definition.
(thesaurus)
'female to abandon a facelift it melted' is the wordplay.
'female' becomes 'f' (abbreviation).
'to abandon' is a deletion indicator.
'melted' indicates an anagram.
'a'+'facelift'+'it'='afaceliftit'
'afaceliftit' with 'f' taken out is 'aaceliftit'.
'aaceliftit' anagrammed gives 'FACILITATE'.
(Other definitions for facilitate that I've seen before include "Make easier" , "Make (something) easy" , "Ease" .)