Endless panic tends to leave a mark (4)
I believe the answer is:
scar
'to leave a mark' is the definition.
(I've seen this in another clue)
'endless panic' is the wordplay.
'endless' means to remove the last letter.
'panic' becomes 'scare' (synonyms).
'scare' with its last letter removed is 'SCAR'.
'tends' is the link.
This may not be correct. It may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for scar that I've seen before include "reminder of sword-fight?" , "reef" , "Blemish - cicatrix" , "Stain" , "Skin blemish - bare crag" .)