Endlessly annoy one pope? He did! (7)
I believe the answer is:
galileo
'he did' is the definition.
The definition suggests a singular noun which matches the answer.
'endlessly annoy one pope?' is the wordplay.
'endlessly' means to remove the last letter.
'annoy' becomes 'gall' (gall can mean to annoy).
'one' becomes 'i' (Roman numeral).
'pope?' becomes 'Leo' (papal name of several popes).
'gall' with its last letter taken off is 'gal'.
'gal'+'i'+'leo'='GALILEO'
Can you help me to learn more?
(Other definitions for galileo that I've seen before include "Great Italian astronomer and physicist of 16th/17th century" , "Great Italian astronomer and physicist of 17th century, suppressed by Church" , "Refracting telescope inventor" , "Pioneer scientist" , "victim of Inquisition" .)