Enemy runs away from front … (3)
I believe the answer is:
foe
'enemy' is the definition.
(synonyms)
'runs away from front' is the wordplay.
'runs' becomes 'r' (cricket abbreviation).
'away from' indicates named letters should be taken away.
'front' becomes 'fore' (fore is a kind of front).
'fore' with 'r' taken out is 'FOE'.
(Other definitions for foe that I've seen before include "Environmentalists" , "Antagonist" , "Someone opposing" , "Adversary" , "Opposition" .)