English setter say barking in comfortable situation (4,6)
I believe the answer is:
easy street
'comfortable situation' is the definition.
(I've seen this before)
'english setter say barking' is the wordplay.
'english' becomes 'e' (abbreviation).
'barking' indicates anagramming the letters (UK slang for mad).
'setter'+'say'='settersay'
'settersay' with letters rearranged gives 'asystreet'.
'e'+'asystreet'='EASY STREET'
'in' is the link.
(Other definitions for easy street that I've seen before include "affluence" , "A bed of roses" , "Financial security -- teeters, say (anag)" , "Comfortable situation" , "Simple way to achieve financial security" .)