Enliven originally apathetic nurse with one Bud (7)
I believe the answer is:
animate
'enliven' is the definition.
(synonyms)
'originally apathetic nurse with one bud' is the wordplay.
'originally' suggests taking the first letters.
'with' says to put letters next to each other.
'one' becomes 'i' (roman numeral).
'bud' becomes 'mate' (I can't justify this - if you can you should give a lot more credence to this answer).
The initial letters of 'apathetic nurse' is 'an'.
'an'+'i'+'mate'='ANIMATE'
Can you help me to learn more?
(Other definitions for animate that I've seen before include "Enliven like cartoon" , "Give new life or energy to" , "Invigorate; alive" , "Put life into as with cartoon" , "Instil life into - say cartoon" .)