Enrico ___ , Italian-American physicist, creator of the first nuclear reactor, d. 1954 (5)
I believe the answer is:
fermi
(Other definitions for fermi that I've seen before include "Enrico, Italian Nobel prize physicist" , "Enrico -----, Italian nuclear physicist (1901-1954); in the US from 1939" .)
I've seen this clue in The Guardian.
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