Entertainment district in London's West End (4)
I believe the answer is:
soho
'entertainment district in london's west end' is the definition.
(I've seen this before)
This is all the clue.
(Other definitions for soho that I've seen before include "Central London entertainment district" , "London's nightlife centre" , "Colourful district in London's West End" , "London area; hunt call" , "Call a large market for software" .)