Ethnicity in the US: nothing of Spain turning up in Midwest resident (9)
I believe the answer is:
coloradan
'midwest resident' is the definition.
(resident of Colorado)
'ethnicity in the us nothing of spain turning up' is the wordplay.
'ethnicity in the us' becomes 'color' (US spelling of 'colour').
'nothing of spain' becomes 'nada' ('nothing' in Spanish).
'turning up' is a reversal indicator.
'nada' backwards is 'adan'.
'color'+'adan'='COLORADAN'
'in' is the link.
(Another definition for coloradan that I've seen is " from a particular American state".)
I've seen this clue in The Independent.
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