Every now and then locals miss a watering-hole (5)
I believe the answer is:
oasis
'watering-hole' is the definition.
(I've seen this before)
'every now and then locals miss a' is the wordplay.
'every now and then' indicates alternate letters (letters selected at regular intervals).
'locals'+'miss'+'a'='localsmissa'
The alternating letters of 'localsmissa' are 'OASIS'.
(Other definitions for oasis that I've seen before include "place of refuge" , "Safe haven" , "haven for travellers" , "place of relief" , "Band with Liam and Noel Gallagher" .)