Every so often disregarding everyone is not hard (4)
I believe the answer is:
soft
'is not hard' is the definition.
('soft' is the opposite to 'hard')
'every so often disregarding everyone' is the wordplay.
'disregarding' indicates named letters should be taken away.
'every'+'so'+'often'='everysooften'
'everysooften' with 'everyone' removed is 'SOFT'.
(Other definitions for soft that I've seen before include "Gentle; easy to cut" , "Pliant" , "Gentle - simple" , "Easy to mould or cut" , "Native of Riyadh" .)