Exasperated by a useless railway! (5)
I believe the answer is:
angry
'exasperated' is the definition.
(thesaurus)
'by a useless railway' is the wordplay.
'by' means one lot of letters go next to another.
'useless' becomes 'ng' (I can't justify this - if you can you should believe this answer much more).
'railway' becomes 'ry' (abbreviation for railway).
'a' put next to 'ng' is 'ang'.
'ang'+'ry'='ANGRY'
Can you help me to learn more?
(Other definitions for angry that I've seen before include "Inflamed" , "Vexed" , "Very annoyed" , "Irate, mad" , "Incensed" .)