Exasperation (3)

I believe the answer is:

ire

'exasperation' is the definition.
(I've seen this before)

This is the entire clue.

(Other definitions for ire that I've seen before include "passion" , "Choler" , "Anger, annoyance" , "Intense anger" , "exasperation" .)

I've seen this clue in the Newsday.com, the Newsday and the Penny Press.

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