Excuse for upsetting a senora? (6)
I believe the answer is:
reason
'excuse' is the definition.
(I've seen this before)
'upsetting a senora?' is the wordplay.
'upsetting' indicates an anagram.
'senora' anagrammed gives 'REASON'.
'for' is the link.
(Other definitions for reason that I've seen before include "Cause or motive" , "Logic, sense" , "Defence" , "Cause; think logically" , "Logic and rationality" .)