Exhausted after tango and twist (5)
I believe the answer is:
tweak
'twist' is the definition.
(tweak can mean to twist or adjust)
'exhausted after tango' is the wordplay.
'exhausted' becomes 'weak' (weak can mean exhausted or lacking energy).
'after' is a charade indicator (letters next to each other).
'tango' becomes 'T' (phonetic alphabet: alpha, bravo, charlie etc.).
'weak' after 't' is 'TWEAK'.
'and' is the link.
(Other definitions for tweak that I've seen before include "Edit" , "Adjust slightly" , "spin, thus?" , "Fine tune" , "Slightly alter" .)