Exhausted, daughter came down (7)
I believe the answer is:
drained
'exhausted' is the definition.
(similar in meaning)
'daughter came down' is the wordplay.
'daughter' becomes 'd' (genealogical abbreviation).
'came down' becomes 'rained' (raining is a kind of coming down).
'd'+'rained'='DRAINED'
(Other definitions for drained that I've seen before include "Exhausted" , "empty" , "Deprived of strength" , "Tired" , "Emptied of liquid" .)