Exhausted wife has worried editor at university (6,2)
I believe the answer is:
washed up
'exhausted' is the definition.
(I've seen this before)
'wife has worried editor at university' is the wordplay.
'wife' becomes 'w'.
'worried' is an anagram indicator.
'editor' becomes 'ed'.
'at university' becomes 'up'.
'has' is an anagram of 'ash'.
'w'+'ash'+'ed'+'up'='WASHED-UP'
(Other definitions for washed up that I've seen before include "Did kitchen duty" , "Worked in kitchen after meal" , "no longer effective?" , "past it" , "Carried ashore by the tide" .)