Exile not at home with actors (7)
I believe the answer is:
outcast
'exile' is the definition.
(I've seen this before)
'not at home with actors' is the wordplay.
'not at home' becomes 'out' (out can mean away from home).
'with' is a charade indicator (letters next to each other).
'actors' becomes 'cast' (group of actors).
'out'+'cast'='OUTCAST'
(Other definitions for outcast that I've seen before include "One rejected by group" , "Social pariah or reject" , "One has been rejected by friends or society" , "Discarded" , "Pariah, society reject" .)