Experimental new trail (5)
I believe the answer is:
trial
'experimental' is the definition.
(synonyms)
'new trail' is the wordplay.
'new' indicates anagramming the letters.
'trail' is an anagram of 'TRIAL'.
(Other definitions for trial that I've seen before include "Criminal court case" , "Legal case" , "Experimental treatment" , "Ordeal or lawsuit" , "Test to determine guilt or innocence" .)